Fig. 2: Mutational analysis of patients with AML in the US and German cohorts.

A Heatmap showing the frequency of the common mutations in 5-year age intervals. Three groups with different patterns of age-related occurrence of genetic alterations are indicated by color: green, mutations with non-linear age-frequency distribution; red, genetic alterations whose frequency increased with increased age; and blue, alterations whose frequency decreased with increased age. The arrows indicate direction of changes with age for these three patterns. B Area plots showing the frequencies of mutations grouped by their biological category (as previously described by Cancer Genome Atlas Research Network [4]) in age intervals.