Fig. 1 | Modern Pathology

Fig. 1

From: Myeloid neoplasms in the setting of sickle cell disease: an intrinsic association with the underlying condition rather than a coincidence; report of 4 cases and review of the literature

Fig. 1

Peripheral blood and bone marrow examination in case 1. a Peripheral blood smear shows red blood cell distortion with increased central pallor and many target cells, one immature granulocyte and nucleated red blood cell (inset). Wright–Giemsa stain, ×1000. b and c Wright–Giemsa-stained bone marrow aspirate smear shows erythroid hyperplasia and left-shifted myelopoiesis, and dysplasia in erythropoiesis (arrows) and megakaryopoiesis (arrow heads), ×1000. d Bone marrow core biopsy shows a hypercellular bone marrow with erythroid and megakaryocytic hyperplasia. Note many megakaryocytes display their small size and hypolobate nuclei. Hematotoxilin and eosin (H&E) stain, ×200. Inset shows a few p53-postive cells. Note weak to moderate nuclear staining in hematopoietic progenitor cells. p53 stain, ×400

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