Fig. 2 | Modern Pathology

Fig. 2

From: Myeloid neoplasms in the setting of sickle cell disease: an intrinsic association with the underlying condition rather than a coincidence; report of 4 cases and review of the literature

Fig. 2

Peripheral blood and bone marrow examination in case 2. a Peripheral blood smear shows red cell distortion, nucleated red blood cells and circulating micromegakaryocytes (arrow heads). Inset shows one circulating blast. Wright–Giemsa stain, ×1000. b Bone marrow core biopsy shows a hypercellular bone marrow with erythroid hyperplasia and increased micromegakaryocytes (arrow heads). Micromegakaryocytes are identified by their eosinophilic cytoplasm and eccentric hyperchromatic nuclei, which can only be recognized after comparing with CD61 stain (c). H&E stain, ×400. c Many micromegakaryocytes are highlighted by CD61 stain on the section of bone marrow biopsy, ×400. d p53 stain on the bone marrow biopsy. Note an islet of early normoblasts that are weakly positive in their nuclei at the top center, in addition to strong nuclear staining in scattered or clustered hematopoietic progenitor cells, ×400

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