Fig. 3 | Modern Pathology

Fig. 3

From: Myeloid neoplasms in the setting of sickle cell disease: an intrinsic association with the underlying condition rather than a coincidence; report of 4 cases and review of the literature

Fig. 3

Peripheral blood and bone marrow examination in case 3. a Peripheral blood smear shows circulating immature granulocytes, atypical monocytes and one atypical neutrophil in a background of hypochromic red blood cells with anisopoikilocytosis and increased target cells. The inset shows a circulating small megakaryocyte with naked nucleus. Wright–Giemsa stain, ×1000. b Bone marrow aspirate smears show a few dysplastic megakaryocytes (arrow heads) and many hypogranular neutrophils (arrows). Wright–Giemsa stain, ×1000. c Bone marrow core biopsy demonstrates hypercellularity with hyperplastic hematopoiesis. Note the increased immature precursors and a few small megakaryocytes. H&E stain, ×400. d p53 stain on the bone marrow biopsy showing many positive hematopoietic progenitor cells, ×400

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