Table 1 Comparison of primary cutaneous follicle center lymphoma and primary cutaneous large B-cell lymphoma, leg type
From: Navigating the cutaneous B-cell lymphomas: avoiding the rocky shoals
Feature | PCFCL | PCLBCL-LT |
|---|---|---|
Cytology | Centrocytes and centroblasts, often large centrocytes | Centroblasts and Immunoblasts |
Pattern | Follicular, follicular, and diffuse, or diffuse | Diffuse |
Background | Reactive lymphocytes present, and frequent fibrosis and sclerosis | Monomorphic tumor cells, and no stromal reaction |
Immunophenotype | BCL2−/+, BCL6+, CD10−/+ | BCL2+, BCL6+/−, CD10− |
IRF4/MUM1−, FOXP1− | IRF4/MUM1+, FOXP1+ | |
Genetics | BCL2/IGH usually −; Del 1p36+ | Mutations in MYD88, PIM1, and CD79B (30–75%) |
Clinical | Localized, conservative therapy, and good prognosis | Chemotherapy required, and aggressive course |
