Table 2 Differential diagnosis of primary cutaneous EBV+ B-cell lymphoproliferative diseases
From: Navigating the cutaneous B-cell lymphomas: avoiding the rocky shoals
MCU | Plasmablastic | EBV + MZL | |
|---|---|---|---|
EBV+ cells | Pleomorphic | Monomorphic | Plasmacytoid |
HRS like | Immunoblastic | Small/Medium | |
Latency | LMP1-pos | LMP1-neg | LMP1-rare pos |
Background T cells | Abundant | Absent | Few |
Epithelium/Skin | Ulcerated | Intact | Subcutaneous |
Deep dermal | |||
Clinical | Elderly+/− immunosuppression | Immunodeficient or elderly | Diverse causes of immune deficiency |
Prognosis | Good | Poor | Good |
Waxing and Waning | Reduce immunosuppression |
