Fig. 1: Morphology and IHC of NTRK rearranged colorectal carcinomas. | Modern Pathology

Fig. 1: Morphology and IHC of NTRK rearranged colorectal carcinomas.

From: NTRK gene rearrangements are highly enriched in MLH1/PMS2 deficient, BRAF wild-type colorectal carcinomas—a study of 4569 cases

Fig. 1

Serial H&E (a, c, e) and Trk IHC (b, d, e) stained sections. a, b Case 3 showing some mucinous differentiation and cytoplasmic only Trk staining (MUC2-NTRK2 fusion). c, d Case 4 showing a solid-cribriform growth pattern and cytoplasmic only staining (STRM-NTRK1 fusion). e, f Case 9 pan-TRK IHC showing nuclear, cytoplasmic, and nuclear membrane staining (LMNA-NTRK1 fusion). [Original magnifications ×400]

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