Table 3 Comparison of Trk IHC and fusion positive (n = 9) and Trk IHC and fusion negative (n = 4569) CRCs
Variables | NTRK positive n = 9 | NTRK negative n = 4560 | P value* |
|---|---|---|---|
Sex | |||
Male | 3 | 2242 | 0.343 |
Female | 6 | 2318 | |
Age | |||
<72 years | 4 | 2006 | 0.978 |
≥72 years | 5 | 2554 | |
Tumor location | |||
Right colon | 8 | 2286 | 0.02 |
Left colon | 1 | 2274 | |
Other synchronous colorectal carcinoma(s) | |||
Absent | 9 | 4259 | 0.425 |
Present | 0 | 301 | |
Tumor size | |||
<40 mm | 2 | 2628 | 0.029 |
≥40 mm | 7 | 1894 | |
Apical node involvement | |||
Present | 0 | 343 | 0.391 |
Absent | 9 | 4203 | |
T stage | |||
T1–2 | 0 | 1070 | 0.097 |
T3–4 | 9 | 3488 | |
N stage | |||
N0 | 4 | 2511 | 0.522 |
N1–2 | 5 | 2049 | |
M stage | |||
M0 | 9 | 4341 | 0.5 |
M1 | 0 | 219 | |
AJCCC stage 8th Ed | |||
I–II | 4 | 2485 | 0.545 |
III–IV | 5 | 2075 | |
Histological grade | |||
Low grade | 5 | 3303 | 0.108 |
High grade | 4 | 941 | |
Pattern of growth | |||
Pushing | 4 | 1949 | 0.499 |
Infiltrative | 5 | 1553 | |
Lymphovascular invasion (small vessels) | |||
Present | 5 | 1181 | 0.213 |
Absent | 4 | 2133 | |
Extramural venous invasion | |||
Present | 0 | 648 | 0.137 |
Absent | 9 | 2633 | |
Discontinuous tumor nodules | |||
Present | 1 | 687 | 0.441 |
Absent | 8 | 2479 | |
Margin involvement | |||
Present (<1 mm) | 0 | 218 | 0.407 |
Absent | 9 | 2848 | |
Mismatch repair proteins expression | |||
Mismatch repair deficient (MMRd) | 8 | 861 | 0.0001 |
Mismatch repair proficient (MMRp) | 1 | 3648 | |
BRAFV600E mutation | |||
Present | 0 | 1094 | 0.088 |
Absent | 9 | 3374 | |
