Fig. 1: Nested urothelial carcinoma. | Modern Pathology

Fig. 1: Nested urothelial carcinoma.

From: PAX8 expression and TERT promoter mutations in the nested variant of urothelial carcinoma: a clinicopathologic study with immunohistochemical and molecular correlates

Fig. 1

a, b (Hematoxylin and eosin, ×10) show round to slightly angulated nests and cords of cells with round, low-grade-appearing nuclei (inset of b at ×40) of high-power magnification. c Large nested urothelial carcinoma (×10). Show range of PAX8 staining, which was either graded as strongly positive (d, ×20) with definitive nuclear staining in a majority of cells, focally positive (e, ×20) with nuclear staining present but varying in prevalence/intensity throughout and between tumor nests, or negative (f, ×40) with a cytoplasmic blush and no nuclear staining. PAX8 expression was negative in overlying urothelium (d).

Back to article page