Table 2 Morphological, immunohistochemical and molecular features of BKPyV-associated UC.
Case No | WHO grading 1973 / 2016 | Histological features | p53 | HER2 immunoscore | HER2-CISH (Ratio) | TERT promoter mutation analysis |
|---|---|---|---|---|---|---|
1 | G3/high grade | MPUC | Overexpression | 1+ (negative) | Not amplified (1,29) | −124: G > A |
2 | G3/high grade | >90% MPUC, 10% cUC | Overexpression | 1+ (negative) | Amplified (polysomy: average HER2 signals per cell 6,1) | −124: G > A |
3 | G3/high grade | cUC, extensive divergent differentiation with Mullerian type clear cell carcinoma; CIS | Overexpression | 1+ (negative) | Not evaluable* | −146: possible deletion |
4 | G3/high grade | Focal cUC, mostly villoglandular pattern | Overexpression | 2+ (weakly positive) | Not amplified (1,26) | −146: G > A |
5 | G3/high grade | 90% cUC, 10% MPUC; CIS | Overexpression | 3+ (MPUC area only) | Amplified (2,57) | Wildtype |
