Fig. 3: Overall survival curves for the three groups.

Kaplan–Meier overall survival (OS) curves showing no significant OS difference between patients with or without targeted therapy in ISH group 2 (p = 0.154), as well as patients with targeted therapy in ISH group 2 vs patients with targeted therapy in ISH group 1 (p = 0.412) or patients in ISH group 5 (p = 0.315), patients with targeted therapy group 1 vs patients in ISH group 5 (p = 0.646). Patients without targeted therapy in ISH group 2 had a worse OS compared with patients with targeted therapy in ISH group 1 (p=0.017) or patients in ISH group 5 (p=0.058).