Table 1 Summary of patterns of p53 immunohistochemical patterns in HPV-associated carcinomas.

From: p53 Immunohistochemical patterns in HPV-related neoplasms of the female lower genital tract can be mistaken for TP53 null or missense mutational patterns

Scattered (wild type)

  

 Heterogenous staining of varying intensities throughout the tumor

  

Markedly reduced (null-like)

  

 absence or significantly reduced p53 staining in the presence of positive internal control

Single cells

Majority of tumor cells with complete absence of staining with scattered single cells showing strong positive staining

 

Clustered

Clustered groups of strongly positive tumor cells in a background of cells with absent staining

 

Peripheral

Peripheral strong staining in background of cells with absent staining

Mid-epithelial (basal sparing)

  

 Basal layer in in situ SCC or peripheral layer in invasive SCC nests showed absence of staining accompanied by strong staining in the parabasal cells

Classic

Absence of staining only in the single basal layer

 

Central

Absence of staining in the basal layer as well as variable portions of the parabasal layers

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