Fig. 2: Illustration of discordance in the receptor status between separate metastatic tumors within the same organ. | Modern Pathology

Fig. 2: Illustration of discordance in the receptor status between separate metastatic tumors within the same organ.

From: Receptor conversion in metastatic breast cancer: analysis of 390 cases from a single institution

Fig. 2

Biopsies of two liver lesions (top and bottom panels) from the same patient demonstrated metastatic breast carcinomas with similar histomorphology. While the primary tumor had an ER+/PR+/HER2+ phenotype, the two metastatic lesions demonstrated ER+/PR−/HER2− and ER+ (low)/PR+/HER2+ phenotypes, respectively. Original magnifications ×100 (H&E, ER, and PR) and ×400 (HER2 Dual ISH).

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