Fig. 3: Molecular findings of MEIS1-NCOA sarcomas. | Modern Pathology

Fig. 3: Molecular findings of MEIS1-NCOA sarcomas.

From: Recurrent MEIS1-NCOA2/1 fusions in a subset of low-grade spindle cell sarcomas frequently involving the genitourinary and gynecologic tracts

Fig. 3

A. Left panel, chromosomal locations and transcription directions of MEIS1 (2p14), NCOA1 (2p23.3), and NCOA2 (8q13.3) genes. Right panel, schematic diagram illustrating variants of MEIS1-NCOA2/1 fusions transcripts, including exon 6 of MEIS1 fused to exon 12 of NCOA2, exon 7 of MEIS1 fused to exon 13 or 14 of NCOA2, and exon 7 of MEIS1 fused to exon 13 of NCOA1. All the fusion variants are in-frame, as demonstrated by the fusion junction sequences and predicted amino acid beneath each fusion variant. Representative FISH of MEIS1 (B) and NCOA2 (C) of case 3 showing break-apart of orange and green signals (arrows).

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