Table 1 Clinicopathologic parameters of sarcomas with MEIS1-NCOA2/1 fusion.
Age | Sex | Location | Size (cm) | Original diagnosis | Necrosis | Mitosis (/10HPFs) | Fusion junction | Follow-up | |
|---|---|---|---|---|---|---|---|---|---|
Unclassified spindle cell sarcomas | |||||||||
1 | 58 | F | Uterine corpus | 20 | Undifferentiated uterine sarcoma | N | 33 | MEIS1 ex7-NCOA2 ex13f | LR (mesentery, 5 m) |
2 | 35 | F | Vagina | 11 | Low-grade endometrial stromal sarcoma | N | <1 | MEIS1 ex6-NCOA2 ex12d | LR (3 m, 1.5 y, 7.5 y) |
3 | 76c | M | Scrotum | NA (LR: 0.6)c | Low-grade sarcoma, NOS (LR) | N | 2–3 | MEIS1 ex6-NCOA2 ex12d | LR (several ys) |
4 | 38 | F | Para-rectal | 14 | Sarcoma, NOS | N | 8 | MEIS1 ex6-NCOA2 ex12d | LR (4 y, 6 y, 8 y) |
5 | 20 | F | Kidney | 21 | Undifferentiated spindle cell sarcoma | Y (10%) | 25 | MEIS1 ex7-NCOA1 ex13e | NA |
6 | 50 | F | Kidney and 2 add ST implants | 19 | Sarcoma, NOS | Y | 10 | MEIS1 ex7-NCOA2 ex14e | LR (1.5 y, 6 y) |
7a | 72 | F | Kidney | 4 | Mixed epithelial stromal tumor with atypia | N | 4 | MEIS1 ex7-NCOA2 ex13/14d | NED (9 m) |
8a | 21 | M | Kidney | 15 | Undifferentiated sarcoma | Y | 13 | NA | NA |
Spindle cell rhabdomyosarcomas | |||||||||
1 | 33 | F | Vulva | 2.5 | spRMS | NA | 10–20 | MEIS1 ex7-NCOA2 ex13e | NA |
2b | 22 | M | Iliac bone | NA | spRMS | Y | 18 | MEIS1 ex6-NCOA2 ex12e | NED (8 m) |
3b | 39 | M | Iliac bone | NA | spRMS | N | 50 | NA | NA |
