Fig. 4: CDH1 alterations observed in case series.

CDH1 genetic alterations were mostly frameshift mutations. Biallelic inactivation with concurrent CDH1 mutation and 16q whole arm or partial arm loss was seen in 11 of 13 cases (A). CDH1 is mapped to chromosome 16q22.1. CDH1 mutations were present across the coding regions of the gene (B).