Table 2 Pathologic features of ILCEM.

From: Invasive lobular carcinoma with extracellular mucin (ILCEM): clinicopathologic and molecular characterization of a rare entity

 

Pathologic features

ID

Primary tumor sizea (cm)

Multifocal

Number of positive nodes

Nottingham gradeb

Score of tubule formation

Score of nuclear grade

Score of mitotic activity

Presence of LCIS

Presence of necrosis

ER status (+/−)

PR status (+/−)

HER2 status (+/−)

Apocrine cytology

SRC features (≥20%)

Alveolar growth pattern

Solid growth pattern

Extracellular mucin (%)

1

1.5

Yes

0

2

3

3

1

No

No

+

No

Yes

No

No

60

2

1.5

Yes

NA

2

3

3

1

Yes

Yes

+

+

Yes

Yes

Yes

Yes

70

3

3.0

NA

3

3

3

3

2

No

No

+

+

+

No

No

No

No

<10

4

2.3

No

1

2

3

3

1

Yes

No

+

+

+

No

No

No

No

25

5

0.7

Yes

0

2

3

2

1

Yes

No

+

+

No

No

No

No

10

6

7.0

Yes

3

3

3

3

2

Yes

No

+

Yes

No

Yes

Yes

<10

7

1.4

Yes

NA

2

3

2

2

No

Yes

+

+

No

No

No

Yes

<10

8

7.3

Yes

1

2

3

3

1

Yesc

Yes

+

No

Yes

No

No

90

9

5.2

No

0

2

3

2

1

Yes

No

+

+

No

No

No

No

50

10

10.0

No

23

2

3

3

1

No

No

+

+

No

Yes

No

Yes

70

11

2.8

Yes

1

3

3

3

2

No

No

+

+

No

Yes

No

No

30

12

1.8

Yes

0

2

3

2

1

No

No

+

+

No

No

No

No

<10

13

8.0

Yes

7

2

3

2

1

No

No

+

No

Yes

No

No

30

14

1.6

No

0

2

3

3

1

Yes

No

+

No

Yes

No

No

95

15

NA

NA

NA

2

3

2

1

No

No

+

+

No

Yes

No

No

10

16

NA

NA

NA

2

3

3

1

No

No

+

+

No

Yes

No

No

30

17

NA

NA

NA

3

3

3

2

No

No

+

+

No

Yes

No

No

40

  1. aLargest tumor focus is reported if tumor is multifocal.
  2. bNottingham histologic grade: 1: well-differentiated; 2: moderately differentiated; 3: poorly differentiated.
  3. cPleomorphic features and extracellular mucin are present within in situ component.
  4. LCIS Lobular carcinoma in situ, SRC Signet ring cell, NA Information is not available in cases with (i) no follow-up, (ii) absence of detailed radiologic data, or (iii) only biopsies available for review.