Table 3 Summary of ILCEM described in prior case reports and series.
Clinicopathologic features | ||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Case reports and series | Number of cases | Age (yrs) | Tumor sizea (cm) | Tumor grade | Nuclear grade | Signet ring cells (number of cases) | Evidence of positive lymph node(s) | ER-positive | PR-positive | HER2-positive | Follow-up data available | Follow-up duration (months) | Recurrence (local or distant) | Death due to breast cancer |
Rosa et al.12 | 1 | 60 | 9 | NA | 2 | 1 | Yesb | Yes | Yes | No | No | NA | NA | NA |
Yu et al.19 | 1 | 65 | 3 | NA | NA | 1 | Yes | Yes | No | Yes | No | NA | NA | NA |
Haltas et al.17 | 1 | 43 | 2.5 | NA | NA | 1 | Yes | Yes | Yes | No | No | NA | NA | NA |
Bari et al.14 | 1 | 38 | 3.5 | NA | NA | 1 | Yes | Yes | Yes | No | No | NA | NA | NA |
Gomez Macias et al.16 | 1 | 60 | 0.9 | 1 | 1 | 1 | No | Yes | Yes | No | No | NA | NA | NA |
Cserni et al.22 | 8 | Median: 63 (range: 45-75) | 2.2–9 | 3 (n = 1); 2 (n = 7) | 3 (n = 1); 2 (n = 7) | 8 | Yes in 5/8 cases | Yes | Yes in 7/8 cases | Yes in 1/8 cases | Yes in 7/8 cases | Median: 26 (range: 2 to 68) | 3/7 cases | 2/7 cases |
Boukhechba et al.15 | 1 | 75 | 1.9 | NA | NA | 1 | NA | Yes | No | No | No | NA | NA | NA |
Singh et al.23 | 4 | Median: 77 (range: 70–87) | 0.8–10 | 3 (n = 2); 2 (n = 1); 1 (n = 1) | NA | 3/4 cases | Yes in 1/3 cases | Yes | NA | No | No | NA | NA | NA |
Koufopoulos et al.18 | 1 | 65 | 1.3 | 2 | NA | 1 | No | Yes | No | No | Yes | 10 | No | No |
Baig et al.20 | 1 | 67 | 6 | 3 | 3 | 1 | Noc | Yes | No | No | No | NA | NA | NA |
Burky et al.21 | 1 | 70 | 2.3 | 3 | 3 | 1 | No | Yes | Yes | Yes | Yes | 8 | No | No |
Soong (this study) | 17 | Median 66 (range 31-77) | 0.7-7.3 | 3 (n = 4); 2 (n = 13) | 3 (n = 11); 2 (n = 6) | 10 (59%) | Yes in 7/12 casesd | Yes | Yes in 12/17 cases | Yes in 2/17 cases | Yes in 12/17 cases | Median: 83.5 (range 3 to 171) | 8/12 cases | 4/12 cases |
Totals | 38 | Median 62 (range 31–87) | Range 0.7–10 | 3 (n = 9); 2 (n = 22); 1 (n = 2) | 3 (n = 14); 2 (n = 15); 1 (n = 1) | 30/38 (79%) | Yes in 17/31 (55%) | Yes in 38/38 (100%) | Yes in 27/37 (73%) | Yes in 4 of 38 (11%) | Yes in 21 | Median 29 (range 2 to 171) | 11/21 (52%) | 6/21 (29%) |
