Fig. 1: Incidence of psychedelic-induced psychosis according to the number of sessions.

a Incidence of psychedelic-induced psychosis according to the number of sessions across healthy individuals, patients with depression, and patients with schizophrenia. Of importance, RCTs, UCT and cohort studies are combined in this forest plot. b Incidence of psychedelic-induced psychosis according to the number of sessions, in healthy individuals only. Please note that Studerus et al. [75], Novak et al. [79] studies are RCTs. All other studies are retrospective cohort studies. When excluding these 2 RCTS, the incidence does not change. When considering only those 2 RCTS, the incidence is 0.4% (95%; CI 0.1–1.7)(I2 = 0%). c Lifetime occurrence of prolonged psychosis according to number of sessions considering only studies that included patients with schizophrenia.