Fig. 1: Euclidean Distance dissimilarity analysis and hierarchical clustering.

Colours and values represent the Euclidean distance calculated from a 19-cell vector averaged across each group. The value for the Euclidean distance is relative to the dataset, thus the number displayed represents the length of the line segment between groups relative to the total group distance. Darker colours and larger Euclidean distance values indicate greater dissimilarity between 19-cell immune profiles across diagnostic groups, while lighter colours indicate relative similarity. The dendrogram represents single linkage hierarchical clustering. Note that all patients separate from controls initially and that the group of syndromes associated with frontotemporal lobar degeneration are similar to each other (PSP, FTD, and CBS), in contrast to Alzheimer’s disease (AD) and Lewy Body dementia (LBD). These relative similarities are highlighted in yellow.