Table 1 Demographic and clinical summaries for patients and controls.

n

37

24

23

29

18

54

—

Sex, F/M

14/23

9/15

17/6

4/25

6/12

26/28

Chi Squared = 20.31, p < 0.001^a

Age, years, Mean (SD)

69 (7)

72 (7)

69 (9)

74 (7)

69 (8)

72 (7)

ns

MMSE, Mean (SD)

29 (1)

23(5)

25(5)

25(4)

21(9)

27 (4)

H = 49.2, df = 5, p < 0.001^a

ACE-R, Mean (SD)

96 (3)

67 (16)

75 (18)

72 (15)

69 (26)

81 (13)

H = 76.8, df = 5, p < 0.001^a

CDR Sum of Boxes, Mean (SD) (n = 127)

0.038 (0.139)

5.12 (2.75)

5.83 (4.14)

8.45 (4.30)

12.2 (5.88)

7.29 (5.06)

H = 46.1, df = 5, p < 0.001^a

n Deceased by Census Date

0

2

2

10

8

20

—

n Biomarkers Collected

27

17

16

22

12

28

ptau 217, pg/mL, Mean (SD)

0.331 (0.221)

0.924 (0.339)

0.667 (0.631)

0.666 (0.395)

0.412 (0.201)

0.456 (0.383)

H = 41.2, df = 5, p < 0.001^a

Nfl, pg/mL, Mean (SD)

18.33 (6.75)

32.5 (13.91)

57.133 (41.31)

34.223 (18.65)

58.367 (26.41)

51.272 (27.634)

H = 50.6, df = 5, p < 0.001^a

GFAP, pg/mL, Mean (SD)

107.27 (54.62)

192.8 (105.32)

238.48 (153.67)

161.2 (95.308)

174.50 (102.92)

164.99 (92.064)

H = 18.3, df = 5, p = 0.002^a

AB40/AB42, pg/mL, Mean (SD)

16.98 (2.703)

19.6 (2.38)

17.695 (2.66)

18.721 (5.029)

16.288 (2.21)

19.643 (5.32)

H = 16.0, df= 5, p = 0.007^a