Fig. 2: Immunohistochemical localisation of two OL markers, for which altered expression patterns in SCZ have been described in the literature. | Molecular Psychiatry

Fig. 2: Immunohistochemical localisation of two OL markers, for which altered expression patterns in SCZ have been described in the literature.

From: Glial cell deficits are a key feature of schizophrenia: implications for neuronal circuit maintenance and histological differentiation from classical neurodegeneration

Fig. 2

A White matter DISC1-immunoreactive OLs. The density of DISC1-expressing OLs was found to be enhanced in SCZ [70]. DISC1 negatively regulates differentiation of OPCs into OLs [38, 110, 116, 117]. B White matter OLIG2 expressing OLs. The density of OLIG2 immunopositive OLs was found to be reduced in SCZ [35, 82]. OLIG2 promotes OL differentiation [118].

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