Fig. 1: Schematic of experimental design.

Dorsolateral prefrontal cortex (DLPFC) was dissected from fresh frozen human postmortem brains. Samples included subjects who died by suicide during an episode of MDD (MDD suicide) and neurotypical comparison subjects. Tissue was used for four molecular assays, including tRNA sequencing, tRNA methylation profiling, proteomics, and amino acid metabolomics.