Fig. 1: The vision of bringing precision to psychiatry requires both a continuously evolving framework incorporating scientific and technological advances, as well as a shift by the mental healthcare ecosystem to a clinically and biologically informed framework of diagnoses.

Not everything can happen in parallel, nor does it all have to happen sequentially. Initially, broad changes can be made, e.g., based on our understanding of the relationship between symptoms and behavior via brain circuits and systems. These will be driven, at least in part, by the rapidly emerging digital technologies that are revolutionizing our ability to collect, collate, and interpret complex data sets. As these foundations are put in place, the full power of the omics revolution can be unleashed and the complexity of the interaction with the environment understood and integrated into the envisioned framework.