Fig. 4: Early adulthood synaptic proteome profiles associated with early chronic MDZ exposure. | Molecular Psychiatry

Fig. 4: Early adulthood synaptic proteome profiles associated with early chronic MDZ exposure.

From: Comprehensive characterization of chronic midazolam exposure on neonates and long-term neurodevelopment

Fig. 4

A Volcano plot displaying proteomics data for P60 synaptosomes. These points indicate different proteins that display magnitude fold-changes (log2 of fold-change, x-axis) and statistical significance (-log10 of p-values, y-axis). The grey dashed horizontal line shows the cut-off p values, and the two vertical dashed lines indicate down/upregulated proteins. B, C Mapping of biological processes (B) and molecular functions (C) from differentially expressed proteins (DEPs) using ClueGO. D Ingenuity Pathway Analysis (IPA) revealed predicted pathways associated with P60 MDZ rats. The pathways are ranked by the negative log of the FDR-corrected p-value of the enrichment score and color-coded according to the Z score. A significantly activated pathway activity is indicated by a positive Z score, represented by the orange bars, and an overall deactivated pathway activity is represented by a negative Z score, represented by blue bars. The Gray bar represents enriched pathways with no predicted activity change. The asterisks represent the group term p-value representing each category. *p < 0.05 and **p < 0.01, n = 6/group.

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