Fig. 3: Transcriptional expression patterns related to differences in MSN strength. | Molecular Psychiatry

Fig. 3: Transcriptional expression patterns related to differences in MSN strength.

From: Neurobiological subtypes of adolescent depression: a multimodal integration of morphometric similarity network and spatial transcriptomics

Fig. 3

a. The distribution of differences in MSN strength and PLS1 scores in the left hemisphere of the AMDD1and AMDD subtype. b. Scatterplots showing the significant spatial correlation between PLS1 scores and the case-control t-value maps of MSN strength in both AMDD subtypes; AMDD1, Spearman’s r = 0.66, p-spin < 0.0001; AMDD2, Spearman’s r = 0.48, p-spin < 0.0001. c, d The expression of MDD-related genes from ISH datasets was positively or negatively associated with regional changes in MSN, including 6 positive genes (i.e., TAC1, CNR1, SST1 HTR1A and GAD2) and one negative genes (CUX2). All r values were determined by Spearman’s correlation analysis, and p values were obtained from spatial correlation tests and adjusted with FDR correction.

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