Fig. 2: Ovarian steroids decrease from premenopause to postmenopause in both the blood and hypothalamus.

A Estrone, B estradiol, and C progesterone measurements are all lower in both i) blood and ii) hypothalamus tissue extracts following menopause. iii) Steroid measurements in the two tissue types had a high correlation for estrone and a moderate correlation for both estradiol and progesterone. Y-axis breaks indicate an adjustment in scale for display of individual value extremes. p values above box plots indicate significance of Dunn’s test posthoc comparisons following non-parametric Kruskal-Wallis test. Box plots (box, 1st–3rd quartile; horizontal line, median; whiskers, 1.5xIQR).