Fig. 6: Summary of protective associations for GIPR/GLP1R, GIPR, and GLP1R targets across alcohol-related, dietary, and liver traits. | Molecular Psychiatry

Fig. 6: Summary of protective associations for GIPR/GLP1R, GIPR, and GLP1R targets across alcohol-related, dietary, and liver traits.

From: Genetically modeled GLP1R and GIPR agonism reduce binge drinking and alcohol-associated phenotypes: a multi-ancestry drug-target Mendelian randomization study

Fig. 6

This figure presents traits with consistent protective or beneficial associations across both primary and replication datasets for each receptor target (GIPR/GLP1R, GIPR, GLP1R), using either BMI (blue) or HbA1c (yellow) as the exposure biomarker. Arrows indicate direction of effect. Asterisks (*) denote associations that surpassed the Bonferroni-corrected significance threshold (P < 0.0025). Results with dashed borders surpassed testing for multiple comparisons in either the primary or replication exposure data but had P-value > 0.05 in the other. Traits shown include alcohol use behaviors (e.g., binge drinking, high-risk drinking), dietary preferences (e.g., fatty, fried, vegetarian, and low-calorie foods), and liver-related outcomes (e.g., NAFLD, ALT, AST, GGT). GIPR glucose-dependent insulinotropic polypeptide receptor, GLP1R Glucagon-like peptide-1 receptor, HbA1c glycated hemoglobin, BMI body mass index.

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