Relapse to drug use during abstinence is a core feature of addiction. Since the 1980s, this clinical scenario has been studied using animal models where relapse is assessed after experimenter-imposed cessation of drug self-administration by either extinction of the drug-reinforced responding or homecage forced abstinence [1]. However, despite strides toward understanding neuronal mechanisms of relapse in these models, treatment options remain largely unchanged. One potential reason for this state-of-affairs is that animal models of addiction rarely incorporate voluntary aspects of human abstinence, which often occurs due to the availability of alternative nondrug rewards (e.g., employment and supportive social environment). This is exemplified in contingency management where nondrug rewards (monetary vouchers), given in exchange for being drug-free, can maintain abstinence for many months. However, when contingency management discontinues, most drug users relapse.

Based on these considerations, we introduced a contingency management-based relapse model, where we achieve long-lasting voluntary abstinence prior to the relapse tests by giving rats mutually exclusive choices between a drug and palatable food [2]. In the initial study, we trained male rats to self-administer the food and methamphetamine in established addiction models—escalation and DSM-IV-based—and found that rats will voluntarily abstain from drug self-administration for at least 3 weeks and then show incubation of methamphetamine craving (time-dependent increases in drug seeking during abstinence) [2]. Subsequently, we demonstrated the generality of food-choice voluntary abstinence to female rats and to heroin, and that surprisingly voluntary abstinence prevents incubation of heroin craving [3]. In mechanistic studies, we found a role of dorsomedial striatum neuronal ensembles in incubation of methamphetamine craving after voluntary abstinence [4], and a role of glutamatergic projections from the anterior insular cortex to central amygdala in relapse after voluntary abstinence [5].

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