Measuring movement has been a cornerstone of studying behavior in animals in controlled studies.

Movement data have served as a primary window into behavior, and by proxy, social function, mood, and cognition [1]. In humans, variations in locomotor activity have served as markers of a range of psychiatric syndromes including major depression, bipolar disorder, anxiety, catatonia, and substance use disorders [2]. Reports of sensor-based motion measurement in humans date back to the 1950s [2], and motion-based models of human psychopathology have been key to developing animal models of psychopathology [1]. A vast literature has documented how these animal models have facilitated development of motion-based signatures of antidepressant, anxiolytic, and other drug effects and guided drug development [3]. However, the limitations of technology thus far have meant that motion-mapping in humans has remained largely restricted to experimental settings.

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