Fig. 2: Drd1-cre120Mxu mice have elevated expression of medium spiny neuron marker genes in nucleus accumbens at baseline.
From: A Drd1-cre mouse line with nucleus accumbens gene dysregulation exhibits blunted fentanyl seeking
Fold change mRNA in experimentally naïve wildtype (black) and Drd1-cre120Mxu (magenta) mice, relative to average of naïve male and female wildtype mice (wildtype n = 4♀, 6♂; Drd1-cre120Mxu n = 4♀, 9♂). A Dopamine D1 receptor, *, p = 0.045, main effect of genotype. B Muscarinic acetylcholine receptor M4, Sex x Genotype Interaction, p = 0.036; * p = 0.01, wildtype vs. Drd1-cre males, Sidak’s post-hoc. C Preprodynorphin. D Preprotachykinin-1, *, p = 0.026, main effect of sex. E Dopamine D2 receptor. F Adenosine A2a receptor, *, p = 0.028, main effect of sex. G G protein-coupled receptor 6. H Preproenkephalin. I Mu opioid receptor. J Delta opioid receptor. K Kappa opioid receptor. L Opioid related nociceptin receptor 1. Data are mean ± SEM with individual mice overlayed.
