Fig. 3: Drd1-cre120Mxu mice have attenuated locomotor response to a novel environment and show increased sensitivity to a D1 receptor agonist.
From: A Drd1-cre mouse line with nucleus accumbens gene dysregulation exhibits blunted fentanyl seeking
Male and female wildtype (black) and Drd1-cre120Mxu (magenta) mice received saline or 30 mg/kg SKF-38393 s.c. prior to open field testing (wildtype saline n = 6♀, 6♂; wildtype SKF n = 6♀, 6♂; Drd1-cre saline n = 5♀, 6♂; Drd1-cre SKF n = 5♀, 6♂). A Distance traveled in the open field over 90 min in 5 min bins. ****, p < 0.0001, main effect of drug; *, p = 0.044, main effect of genotype. B Average velocity in the open field in saline and SKF treated mice. Triangles represent data points from male mice and circles from females. C Total distance traveled in SKF-treated wildtype and Drd1-cre relative to saline-treated mice. *, p = 0.011, unpaired t-test. D Jump counts in SKF-treated mice relative to saline-treated mice. **, p = 0.003, unpaired t-test. E Stereotypy counts in SKF-treated mice relative to saline-treated mice. ****, p < 0.0001, unpaired t-test. Data are presented as mean ± SEM with individual mice overlaid.
