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DLPFC: The Decade circLe CCNP Family Cohort

Neuropsychopharmacology volume 50, pages 1617–1619 (2025)Cite this article

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Long-term longitudinal studies of brain development spanning across multiple life stages remain limited, even as landmark projects have advanced our understanding of brain maturation. Current key initiatives such as the NIH Magnetic Resonance Imaging (MRI) study of Normal Brain Development [1], the Adolescent Brain Cognitive Development (ABCD) cohort study [2], and the European IMAGEN study [3] have significantly yield significant insights into neurodevelopmental trajectories. However, their predominant focus on Western populations and specific developmental periods leaves critical gaps in characterizing lifespan neural development across diverse cultures.

To address these limitations and gain insights into population neuroscience, we propose the Decade circLe CCNP Family Cohort (DLPFC) study, a family-centered extension of the development phase of the Chinese Color Nest Project (devCCNP) [4, 5]. This study will build on data collection initiated in Chongqing twelve years ago (2013–2017) [6] and investigate spatiotemporal signatures of long-term brain-mind development from childhood through adolescence and into adulthood (6–33 years).

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Fig. 1: Population neuroscience design of DLPFC.

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Acknowledgements

We thank our Ph.D. supervisor, Prof. Xi-Nian Zuo, who founded the Chinese Color Nest Project 12 years ago, and all the scientists who provided valuable experience and suggestions for the DLPFC design: Gongxiang Chen from University of Jinan, Wen Liu and Hanbo Che from Liaoning Normal University, Yiping Zhong and Wei Fan from Hunan Normal University, Yufang Zhao, Xu Lei and Xiao Gao from Southwest University, Yong-Yu Guo and Chuan-Peng Hu from Nanjing Normal University, Zhuo Rachel Han from Beijing Normal University, Binghai Sun from Zhejiang Normal University, Guangqing Long and Zhixiong Yan from Nanning Normal University, Yuan Zhou, Hui-Jie Li and Gao-Xia Wei from the Institute of Psychology of the Chinese Academy of Sciences, Liqi Zhu from Shandong Normal University, Feiyan Chen, Hongjian He and Ruiliang Bai from Zhejiang University, Xujun Duan from University of Electronic Science and Technology of China, Yi Du and Yuwei Gao from the Computer Network Information Center of the Chinese Academy of Sciences, Feng Feng from Peking Union Medical College Hospital, Ying Han from Xuan Wu Hospital, Jing Jing from Beijing Tiantan Hospital, Chao-Gan Yan and Qiyuan Tian from Tsinghua University, Yu-Feng Zang from Hangzhou Normal University, Zheng Li, Pan Wang and Jiayu Zhu from the Institute of United Imaging. We gratefully acknowledge Dr. Karl‑Heinz Nenning from the Nathan Kline Institute and Dr. Ting Xu from Child Mind Institute for their valuable assistance in polishing the language and improving the expression of this manuscript.

Funding

CCNP team has received funding support from the STI 2030 - the major projects of the Brain Science and Brain-Inspired Intelligence Technology (2021ZD0200500), the Major Fund for International Collaboration of National Natural Science Foundation of China (81220108014), the Start-up Funds for Leading Talents at Beijing Normal University, the Major Project of National Social Science Foundation of China (20&ZD296,24&ZD251), the Key-Area Research and Development Program of Guangdong Province (2019B030335001), the Beijing Municipal Science and Technology Commission (Z161100002616023, Z181100001518003), the National Basic Research (973) Program (2015CB351702), the Chinese Academy of Sciences (CAS) Key Research Program (KSZD-EW-TZ-002), the CAS-NWO Programme (153111KYSB20160020), the Beijing United Imaging Research Institute of Intelligent Imaging and the Science Fundation of Hebei Normal University (L2021B43).

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Authors and Affiliations

  1. College of Education, Hebei Normal University, Shijiazhuang, Hebei, China

    Zhe Zhang

  2. Developmental Population Neuroscience Research Center, International Data Group/McGovern Institute for Brain Research, Beijing Normal University, Beijing, China

    Ning Yang

  3. Faculty of Psychology, Beijing Normal University, Beijing, China

    Ning Yang

Authors
  1. Zhe Zhang
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  2. Ning Yang
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Contributions

Conception and Design: ZZ, NY. Initial Drafting of the Manuscript: ZZ. Critical Review and Editing of the Manuscript: ZZ, NY.

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Correspondence to Zhe Zhang or Ning Yang.

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Zhang, Z., Yang, N. DLPFC: The Decade circLe CCNP Family Cohort. Neuropsychopharmacol. 50, 1617–1619 (2025). https://doi.org/10.1038/s41386-025-02131-1

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