Fig. 5: GABA knockdown in CRF-expressing BNST neurons reduced motivation to work for sucrose in a sex-dependent way. | Neuropsychopharmacology

Fig. 5: GABA knockdown in CRF-expressing BNST neurons reduced motivation to work for sucrose in a sex-dependent way.

From: Disentangling the effects of corticotrophin releasing factor and GABA release from the bed nucleus of the stria terminalis on ethanol self-administration in mice

Fig. 5

A BNST-CRF GABA knockdown did not alter sucrose self-administration in male mice (male scramble n = 8, shvGAT n = 8). B BNST-CRF GABA knockdown did not alter sucrose self-administration in female mice (female scramble n = 7, shvGAT n = 7). C BNST-CRF GABA knockdown did not alter sucrose rewards obtained in male mice (male scramble n = 8, shvGAT n = 8). D BNST-CRF GABA knockdown did not alter sucrose rewards obtained in female mice (female scramble n = 7, shvGAT n = 7). E BNST-CRF GABA knockdown reduced motivation to work for sucrose reinforcement on an arithmetic progressive ratio schedule of reinforcement in male mice. F BNST-CRF GABA knockdown reduced motivation for both sexes to work for sucrose on an exponential progressive ratio schedule of reinforcement.

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