Fig. 2: Directly targeting the NLS of EGFR alters the expression of NK cell function genes.
From: Nuclear EGFR in breast cancer suppresses NK cell recruitment and cytotoxicity
a Diagram depicting the NLS in wildtype EGFR (WT; top) and EGFR mutant (ΔNLS; bottom). Three amino acids (two arginines and one lysine) in the tripartite sequence (645–657) were changed to aspartic acids (646 R > D; 653 K > D; 657 R > D). b Venn diagram; significantly differentially expressed (Padj < 0.05) genes shared by both cSNX1.3 and ΔNLS (ΔNLS relative to its WT control). c Functional enrichment in the significantly (Padj < 0.05) differentially expressed genes of the ΔNLS group. GO term enrichment analysis of ΔNLS with log2FC > 1 (left) and log2FC < -1 (right). d Natural killer cell-mediated cytotoxicity genes regulated from directly targeting the NLS of EGFR. Log2FC of significantly (Padj < 0.05) differentially expressed genes associated with natural killer cell-mediated cytotoxicity in both ΔNLS and cSNX1.3. The human gene set used for identifying natural killer cell-mediated cytotoxicity genes can be found under the standard name KEGG_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY. e Schematic of chromosome 6, which encodes for major histocompatibility complex genes (Class I, Class II, Class III, and Class-I related).
