Fig. 1: Analysis of deletion size associated with 17p aneuploidy in various cancers.
From: Deletion of 17p in cancers: Guilt by (p53) association
A Dot plots showing copy number alteration (CNA) data of the four indicated genes (upper panel shows where they are located on chromosome 17p) plotted relative to TP53 CNA. The CNA data is derived from the cancer cell lines available on DepMap. B Graph showing the frequency of genes located on 17p that are co-deleted with TP53 in a continuous fashion, giving insight into the size of deletion that is most commonly observed in cells bearing del17p. The location of TP53 is indicated by the dotted red line, as are the positions of the genes illustrated in part A. The data used to construct this graph is taken from all cell lines available on DepMap. C Graphs showing the frequency of genes located on 17p that are co-deleted with TP53 in a continuous fashion using data (from DepMap) associated with cell lines derived from the indicated cancers. The location of TP53 is indicated by the dotted red line, as are the positions of the genes illustrated in part A. D Graphs showing the frequency of genes located on 17p that are co-deleted with TP53 in a continuous fashion using data (from cBioPortal) associated with primary cells derived from the indicated cancers. The location of TP53 is indicated by the dotted red line, as are the positions of the genes illustrated in part A. E Hierarchical cluster plots indicating 17p deletion size (x-axis) within cells from individual patients (y-axis) calculated from data recorded in cBioPortal for primary cells from the indicated cancers.
