Fig. 2: LDAH knockdown promotes ovarian cancer cell proliferation and chemoresistance. | Oncogenesis

Fig. 2: LDAH knockdown promotes ovarian cancer cell proliferation and chemoresistance.

From: Lipid droplet-associated hydrolase (LDAH) knockdown enhances TAG hydrolysis and promotes ovarian cancer progression and chemoresistance

Fig. 2

Western blot of LDAH in scrambled control or LDAH knockdown (shLDAH #69, #71 and #75) ES2 (A) and A2780 (B) ovarian cancer cell lines. The quantification of band intensity normalized to GAPDH is shown below. Two-way ANOVA followed by Tukey’s multiple comparison test. MTT assay to measure the effect of LDAH knockdown on proliferation in ES2 (C) and A2780 (D) cancer cells with or without cisplatin treatment. N = 3. Student’s T-test. E Annexin V/7-AAD apoptosis analysis of scrambled control or LDAH knockdown ES2 and A2780 cancer cells after cisplatin treatment. N = 3. Student’s T-test. F Representative images of excised tumors from xenograft mouse models. G Volume of excised tumors from (F). One-way ANOVA followed by Tukey’s multiple comparison test. Error bars, SD. *, p < 0.05, **, p < 0.01, ***, p < 0.001. ****, p < 0.0001. ns, not significant.

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