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References
Flaring, U. et al. The efficacy of hypotonic and near-isotonic saline for parenteral fluid therapy given at low maintenance rate in preventing significant change in plasma sodium in post-operative pediatric patients: protocol for a prospective randomized non-blinded study. BMC Pediatr. 11, 61 (2011).
Oh, G. J. & Sutherland, S. M. Perioperative fluid management and postoperative hyponatremia in children. Pediatr. Nephrol. 31, 53–60 (2016).
Somme, S., Bronsert, M., Morrato, E. & Ziegler, M. Frequency and variety of inpatient pediatric surgical procedures in the United States. Pediatrics 132, e1466–e1472 (2013).
McNab S. et al. Isotonic versus hypotonic solutions for maintenance intravenous fluid administration in children. Cochrane Database Syst Rev. 12, 1–62 (2014).
Feld L. G. et al. Clinical Practice Guideline: Maintenance Intravenous Fluids in Children. Pediatrics 142, 1–14 (2018).
Carr, N. J. The pathology of acute appendicitis. Ann. Diagn. Pathol. 4, 46–58 (2000).
Chung, H. M., Kluge, R., Schrier, R. W. & Anderson, R. J. Clinical assessment of extracellular fluid volume in hyponatremia. Am. J. Med. 83, 905–908 (1987).
Hatherill, M. Rubbing salt in the wound. Arch. Dis. Child. 89, 414–418 (2004).
Poulsen, K. & Jorgensen, J. An easy radioimmunological microassay of renin activity, concentration and substrate in human and animal plasma and tissues based on angiotensin I trapping by antibody. J. Clin. Endocrinol. Metab. 39, 816–825 (1974).
Bie, P. & Sandgaard, N. C. Determinants of the natriuresis after acute, slow sodium loading in conscious dogs. Am. J. Physiol. Regul. Integr. Comp. Physiol. 278, R1–r10 (2000).
Emmeluth, C., Drummer, C., Gerzer, R. & Bie, P. Natriuresis in conscious dogs caused by increased carotid [Na+] during angiotensin II and aldosterone blockade. Acta Physiol. Scand. 151, 403–411 (1994).
Spasovski, G. et al. Clinical practice guideline on diagnosis and treatment of hyponatraemia. Eur. J. Endocrinol. 170, G1–G47 (2014).
Baylis, P. H. Osmoregulation and control of vasopressin secretion in healthy humans. Am. J. Physiol. 253, R671–R678 (1987).
Robertson, G. L. Antidiuretic hormone. Normal and disordered function. Endocrinol. Metab. Clin. North. Am. 30, 671–694 (2001). vii.
Lobo, D. N. et al. Dilution and redistribution effects of rapid 2-litre infusions of 0.9% (w/v) saline and 5% (w/v) dextrose on haematological parameters and serum biochemistry in normal subjects: a double-blind crossover study. Clin. Sci. (Lond.) 101, 173–179 (2001).
Schrier, R. W. Diagnostic value of urinary sodium, chloride, urea, and flow. J. Am. Soc. Nephrol. 22, 1610–1613 (2011).
Tam, R. K., Wong, H., Plint, A., Lepage, N. & Filler, G. Comparison of clinical and biochemical markers of dehydration with the clinical dehydration scale in children: a case comparison trial. BMC Pediatr. 14, 149 (2014).
Gerigk, M., Gnehm, H. E. & Rascher, W. Arginine vasopressin and renin in acutely ill children: implication for fluid therapy. Acta Paediatr. 85, 550–553 (1996).
Desborough, J. P. The stress response to trauma and surgery. Br. J. Anaesth. 85, 109–117 (2000).
Bankir, L., Fernandes, S., Bardoux, P., Bouby, N. & Bichet, D. G. Vasopressin-V2 receptor stimulation reduces sodium excretion in healthy humans. J. Am. Soc. Nephrol. 16, 1920–1928 (2005).
Choukroun, G., Schmitt, F., Martinez, F., Drueke, T. B. & Bankir, L. Low urine flow reduces the capacity to excrete a sodium load in humans. Am. J. Physiol. 273, R1726–R1733 (1997).
Verbalis, J. G. Whole-body volume regulation and escape from antidiuresis. Am. J. Med. 119, S21–S29 (2006).
McNab, S. et al. 140 mmol/L of sodium versus 77 mmol/L of sodium in maintenance intravenous fluid therapy for children in hospital (PIMS): a randomised controlled double-blind trial. Lancet 385, 1190–1197 (2015).
Acknowledgements
The authors would like to thank all the participating children and their parents. We would also like to thank Marie-Christin Johansson, Emma Mellgren, and Maria Westerståhl for logistic assistance during the study, Shukri Omar and Jesper Keisu for the laboratory sample management, Susanne Hansen and Gitte Kitlen for excellent technical assistance, and Bodil Kristensen and Peter Bie for their valuable advice concerning the arginine-vasopressin assay.
Funding
M.A. and J.F.S. received grants from Sällskapet Barnvård and the Crown Princess Lovisa’s Foundation.
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R.T.K. and U.F. conceptualized and designed the study. R.T.K. carried out the statistical analysis, wrote the initial manuscript draft, and takes responsibility for the integrity and the accuracy of the data analysis. Acquisition, analysis, or interpretation of the data: all authors. Critical revision of the manuscript for important intellectual content: all authors.
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Lindestam, U., Fläring, U., Almström, M. et al. Sodium and water homeostasis in children admitted with acute appendicitis: a prospective study. Pediatr Res 86, 5–8 (2019). https://doi.org/10.1038/s41390-019-0353-4
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DOI: https://doi.org/10.1038/s41390-019-0353-4
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