Abstract
Background
Photobiomodulation by 670 nm red light in animal models reduced severity of ROP and improved survival. This pilot randomised controlled trial aimed to provide data on 670 nm red light exposure for prevention of ROP and survival for a larger randomised trial.
Methods
Neonates <30 weeks gestation or <1150 g at birth were randomised to receive 670 nm for 15 min (9 J/cm2) daily until 34 weeks corrected age. Data collected: placental pathology, growth, days of respiratory support and oxygen, bronchopulmonary dysplasia, patent ductus arteriosus, necrotising enterocolitis, sepsis, worst stage of ROP, need for laser treatment, and survival.
Results
Eighty-six neonates enrolled—45 no red light; 41 red light. There was no difference in severity of ROP (<27 weeks—p = 0.463; ≥27 weeks—p = 0.558) or requirement for laser treatment (<27 weeks—p = 1.00; ≥27 weeks—no laser treatment in either group). Survival in 670 nm red light treatment group was 100% (41/41) vs 89% (40/45) in untreated infants (p = 0.057).
Conclusion
Randomisation to receive 670 nm red light within 24–48 h after birth is feasible. Although no improvement in ROP or survivability was observed, further testing into the dosage and delivery for this potential therapy are required.
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Acknowledgements
This study was funded by the Canberra Hospital Private Practice Fund.
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A.K. conceived, developed and managed the study; analysed the results and prepared and finalised the manuscript; M.E.A.-L., B.S. and R.N. was involved in the conception of the study, analysed the results and approved the final manuscript; T.C. helped conceive the study, analysed the results and approved the final manuscript; MB was involved in the conception of the study, managed the study and approved the final manuscript; J.E.D. was involved in the conception of the study, assessed the placentas, analysed the results and approved the final manuscript; R.W.E. was involved in the conception of the study, performed the eye examinations, analysed the results and approved the final manuscript.
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Kent, A.L., Abdel-Latif, M.E., Cochrane, T. et al. A pilot randomised clinical trial of 670 nm red light for reducing retinopathy of prematurity. Pediatr Res 87, 131–136 (2020). https://doi.org/10.1038/s41390-019-0520-7
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DOI: https://doi.org/10.1038/s41390-019-0520-7
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