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Role of neuroserpin and N-Cadherin in mesenchymal stromal cell modulation of preterm brain injury

Pediatric Research (2024)Cite this article

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Neuroserpin normalization by mesenchymal stem cell therapy after encephalopathy of prematurity in neonatal rats.

Being born preterm, especially extremely preterm (<28 weeks’ gestation) is often associated with encephalopathy of prematurity (EoP), which refers to the multifaceted grey and white matter lesions in the preterm brain.1 There are various causes of EoP including but not limited to hypoxia ischaemia and exposure to infection/inflammation.2 Diffuse white matter injury (WMI) is the brain injury most commonly seen in preterm babies, due to the developmental processes occurring during weeks 23–28 of gestation, including pre-oligodendrocyte development.3 This is also a crucial time for subplate neuron development4 and as such these cells are highly susceptible to injury as a result of preterm birth. This injury can be further exacerbated by exposure to other factors during gestation and birth including hypoxia ischaemia (HI) and infection/inflammation,5 thus increasing the risk of neurological impairment. Current therapies for EoP and consequences of preterm brain injury are limited, thus novel therapies like stem cell therapies are currently being investigated.

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Acknowledgements

TP receives funding from the Cerebral Palsy Alliance and MRFF. AM receives funding from NHMRC, MRFF, CPA, NSCFA and Lions Cord Blood Foundation. This article was not linked to any specific funding.

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Authors and Affiliations

  1. The Ritchie Centre, Hudson Institute of Medical Research, Melbourne, VIC, Australia

    Tayla R. Penny & Atul Malhotra

  2. Department of Obstetrics & Gynaecology, Monash University, Melbourne, VIC, Australia

    Tayla R. Penny

  3. Department of Paediatrics, Monash University, Melbourne, VIC, Australia

    Atul Malhotra

  4. Monash Newborn, Monash Children’s Hospital, Melbourne, VIC, Australia

    Atul Malhotra

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  1. Tayla R. Penny
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  2. Atul Malhotra
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T.P. and A.M. drafted and revised the article.

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Correspondence to Atul Malhotra.

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Penny, T.R., Malhotra, A. Role of neuroserpin and N-Cadherin in mesenchymal stromal cell modulation of preterm brain injury. Pediatr Res (2024). https://doi.org/10.1038/s41390-024-03708-0

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