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Can we prevent extrauterine growth restriction by doing metabolic analysis?

Pediatric Research volume 97, page 1769 (2025)Cite this article

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In the article prepared by Duan et al.1 it was revealed that there are different metabolites that occur in extrauterine growth retardation of SGA and non-very low birth weight newborns.

The authors collected 100 stool and plasma samples from 50 infants. They divided the babies without SGA and very low birth weight into two groups: those with and without extrauterine growth restriction. They compared these samples by working with the ultraperformance liquid chromotography-tandem mass method. Fifty eight different metabolites were detected in feces and 71 in plasma. It has been observed that these metabolites are the products of the pathways of substances such as galactose, glutathione, cysteine, caffeine and methionine. In the feces samples, 1-palmitoylgalactosylglycerol exhibited a negative correlation with the growth characteristics of preterm infants, while 1-palmitoyl-2-palmitoleoyl-GPC displayed the opposite pattern. In plasma samples, androsterone glucuronide displayed a positive correlation with the growth characteristics of preterm infants, whereas 2-methoxyhydroquinone sulfate generated an opposite pattern.

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References

  1. Duan, J. et al. Metabolomic profiling of human feces and plasma from extrauterine growth restriction infants. Pediatr. Res. (2024).

  2. Wang, L. et al. Analysis of Amino Acid Patterns With Nutrition Regimens in Preterm Infants With Extrauterine Growth Retardation. Front Pediatr. 28, 184 (2020).

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  3. Wang, L. et al. Metabolic Biomarkers of Monochorionic Twins Complicated With Selective Intrauterine Growth Restriction in Cord Plasma and Placental Tissue. Sci. Rep. 8, 15914 (2018).

    Article  PubMed  PubMed Central  Google Scholar 

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  1. Pediatrics & Neonatology, University of Health Sciences, Ankara Bilkent City Hospital, 06800, Çankaya, ANKARA, Türkiye

    Fuat Emre CANPOLAT

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  1. Fuat Emre CANPOLAT
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Correspondence to Fuat Emre CANPOLAT.

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CANPOLAT, F.E. Can we prevent extrauterine growth restriction by doing metabolic analysis?. Pediatr Res 97, 1769 (2025). https://doi.org/10.1038/s41390-024-03783-3

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  • DOI: https://doi.org/10.1038/s41390-024-03783-3

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