Table 2 Association between IH at 8–21 days of age and hypertension at 34–36 weeks’ postmenstrual Age: GEE model.
From: Neonatal intermittent hypoxemia events are associated with later systemic hypertension
HTN vs No HTN (by norms) | ||||||
|---|---|---|---|---|---|---|
No HTN | HTN | Unadjusted | Adjustedb | |||
Median (IQR) | Median (IQR) | OR (95% CI) | p | OR (95% CI) | pb | |
# IH events <90%, days 8–14 | 793.74 (349.37, 1507.65) | 1344.89 (961.57, 1932.88) | 1.06 (1.02, 1.11)a | 0.008 | 1.08 (1.01, 1.15)a | 0.02 |
# IH events < 90%, days 15–21 | 1475.56 (656.12, 2154.71) | 1814.8 (1272.59, 2493.37) | 1.03 (1.00, 1.06)a | 0.09 | 1.02 (0.99, 1.06)a | 0.17 |
# of IH events <90%, days 8–21 | 2523.28 (1041.31, 3962.89) | 3348.4 (2234.62, 4325.37) | 1.02 (1.00, 1.04)a | 0.03 | 1.02 (1.00, 1.05)a | 0.08 |
% time with IH <90%, days 8–14 | 5.04 (1.72, 15.88) | 11.96 (6.03, 19.72) | 1.03 (1.00, 1.06) | 0.08 | 1.03 (0.98, 1.08) | 0.20 |
% time with IH <90%, days 15–21 | 9.7 (3.83, 22.76) | 15 (6.85, 22.22) | 1.02 (0.99, 1.05) | 0.27 | 1.01 (0.97, 1.05) | 0.69 |
% time with IH <90%, days 8–21 | 7.27 (2.47, 18.83) | 13.41 (7.09, 20.47) | 1.02 (0.99, 1.06) | 0.15 | 1.02 (0.97, 1.07) | 0.43 |
IH Duration (sec) <90%, days 8–14 | 29.92 (22.36, 46.21) | 35.95 (27.98, 45.99) | 1.01 (0.99, 1.04) | 0.22 | 1.01 (0.97, 1.05) | 0.63 |
IH Duration (sec) <90%, days 15–21 | 27.34 (20.22, 42.57) | 31.37 (24.32, 43.82) | 1.01 (0.98, 1.03) | 0.64 | 0.99 (0.96, 1.02) | 0.60 |
IH Duration (sec) <90%, days 8–21 | 28.57 (21.43, 43.38) | 33.75 (26.61, 44.7) | 1.01 (0.99, 1.03) | 0.42 | 1.00 (0.96, 1.03) | 0.85 |
SBP 34–36 wks. PMA (continuous) | ||||||
|---|---|---|---|---|---|---|
<median SBP 34–36 wks. PMA | ≥median SBP 34–36 wks. PMA | Unadjusted | Adjustedb | |||
Median (IQR) | Median (IQR) | Coef. (95% CI) | p | Coef. (95% CI) | pb | |
# IH events <90%, days 8–14 | 695.35 (260.8, 1523.84) | 1247.45 (733.63, 1669.45) | 0.16 (0.06, 0.25)a | 0.001 | 0.22 (0.10, 0.34)a | 0.0004 |
# IH events <90%, days 15–21 | 1380.11 (538.53, 2111) | 1664.5 (1144.57, 2387.56) | 0.06 (0, 0.13)a | 0.048 | 0.06 (−0.04, 0.13)a | 0.08 |
# of IH events <90%, days 8–21 | 2250.24 (904.84, 3950.06) | 3100.43 (1962.47, 4150.47) | 0.05 (0.01, 0.1)a | 0.008 | 0.06 (0.02, 0.11)a | 0.0077 |
% time with IH < 90%, days 8–14 | 3.59 (1.34, 15.74) | 9.17 (4.70, 17.88) | 0.07 (0.01, 0.14) | 0.03 | 0.10 (0.01, 0.19) | 0.03 |
% time with IH < 90%, days 15–21 | 9.49 (3.45, 22.55) | 13.02 6.33, 22.2) | 0.05 (−0.02, 0.11) | 0.17 | 0.04 (−0.05, 0.13) | 0.36 |
% time with IH < 90%, days 8–21 | 5.99 (1.95, 18.95) | 11.48 (5.85, 20.23) | 0.068 (−0.002, 0.138) | 0.058 | 0.09 (−0.01, 0.19) | 0.08 |
IH Duration (sec) <90%, days 8–14 | 29.89 (21.81, 46.08) | 34.43 (24.36, 46.48) | 0.04 (−0.01, 0.10) | 0.13 | 0.05 (−0.04, 0.14) | 0.27 |
IH Duration (sec) <90%, days 15–21 | 27.14 (20.75, 41.8) | 31.2 (21.47, 45.24) | 0.02 (−0.03, 0.07) | 0.49 | 0.0002 (−0.0780, 0.0783) | 1.00 |
IH Duration (sec) <90%, days 8–21 | 27.88 (21.41, 43.64) | 32.06 (23.38, 43.36) | 0.03 (−0.02, 0.08) | 0.29 | 0.02 (−0.07, 0.11) | 0.65 |
