Fig. 4: SAMs play a key role in liver fibrosis progression.

a UMAP projection showing the distribution of 19,728 myeloid cells in the Tianjin Children’s Hospital scRNA cohort after dimensionality reduction clustering. b Percentage difference between BA(Fibrosis ≤ 2), BA(Fibrosis > 2), C,C and NC cell clusters. Percentage difference between BA, CC, and NC cell clusters. c Differences in Fibrosis Score of 8 scRNA samples and 10 myeloid cell clusters. d Differences in MoMF Score of 8 scRNA samples and 10 myeloid cell clusters. e Differences in Kupffer Score of 8 scRNA samples and 10 myeloid cell clusters. f CD14⁺Mon1, TIMD4⁺SAMs, CD300E⁺intMon, and IL1B⁺Pi Mon were enriched in fibrotic regions. SAMs scar-associated macrophages, UMAP Uniform manifold approximation and projection, BA biliary atresia, CC Choledochal cysts, NC Normal control, scRNA-seq single-cell RNA sequencing, MoMF marrow monocyte-derived macrophages.