Fig. 5: SAMs are derived from monocytes and are associated with EMT activation. | Pediatric Research

Fig. 5: SAMs are derived from monocytes and are associated with EMT activation.

From: Scar-associated macrophages and biliary epithelial cells interaction exacerbates hepatic fibrosis in biliary atresia

Fig. 5

a Pseudotime analysis of CD14+Mon1, TIMD4+SAMs, CD300E+intMon and IL1B+Pi Mon. b Changes in expression of fibrosis-related genes, marker genes for SAMs and marker genes for Pi Mon following pseudotime. c GSVA differential enrichment analysis of IGHM+naïve B, CD19+T1B, IGHD+T2B, and MME+Immature B in BA and control groups. d Correlation analysis of signature genes of SAMs (CD9 and TREM2) and KRT18, CDH2 in GSE46960, GSE122340, and GSE15235 cohorts. SAMs scar-associated macrophages, EMT epithelial-mesenchymal transition, GSVA Gene set variation analysis, BA biliary atresia.

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