Table 4 Characteristics of rare variant carriers and non-carriers.
From: Deleterious variants in LTBP4 are associated with severe pediatric sepsis
characteristic | LTBP4 | PLA2G4E | CCDC157 | |||
|---|---|---|---|---|---|---|
carriers | Non-carriers | carriers | Non-carriers | carriers | Non-carriers | |
No. of Patients | 8 | 311 | 6 | 313 | 17 | 302 |
Age, median (IQR), y | 8 (5, 12) | 5 (1, 12) | 1 (1, 2) | 5 (1, 12)a | 3 (2, 10) | 5 (1, 12) |
Sex, N (%) | ||||||
Female | 3 (37.5) | 141 (45.3) | 4 (66.7) | 140 (44.7) | 7 (41.1) | 137 (45.4) |
Male | 5 (62.5) | 170 (54.7) | 2 (33.3) | 173 (55.3) | 10 (58.9) | 165 (54.6) |
Race, N (%) | ||||||
White | 3 (37.0) | 210 (67.5) | 5 (83.3) | 208 (66.5) | 12 (70.6) | 201 (66.6) |
Black | 4 (50.0) | 63 (20.3) | 1 (16.7) | 67 (21.4) | 4 (23.5) | 63 (20.9) |
Asian | 0 (0.0) | 14 (4.5) | 0 (0.0) | 14 (4.5) | 1 (5.9) | 14 (4.6) |
Other | 1 (13.0) | 24 (7.7) | 0 (0.0) | 24 (7.7) | 0 (0.0) | 24 (7.9) |
Ethnicity, N (%) | ||||||
Non-Hispanic | 6 (75.0) | 250 (80.4) | 6 (100.0) | 250 (79.9) | 13 (76.5) | 243 (80.5) |
Hispanic | 2 (25.0) | 48 (15.4) | 0 (0.0) | 50 (16.0) | 2 (11.8) | 48 (15.9) |
Unknown | 0 (0.0) | 13 (4.2) | 0 (0.0) | 13 (4.2) | 2 (11.8) | 11 (3.6) |
Previous healthy | 5 (62.5) | 148 (47.6) | 3 (50.0) | 150 (47.9) | 8 (47.1) | 145 (48.0) |
Immunocompromised, N (%) | 1 (12.5) | 58 (18.6) | 1 (16.7) | 58 (18.5) | 3 (17.6) | 56 (18.5) |
PRISM Score, median (IQR) | 8.5 (7.25, 15.75) | 8 (3, 15) | 18.5 (15.75, 19.00)a | 8 (3, 14) | 10 (3, 15) | 8 (3, 15) |
OFI, median (IQR) | 2.5 (2, 3)a | 2 (1, 2) | 2 (1, 3.75) | 2 (1, 2) | 2 (2, 3)a | 2 (1, 2) |
Infection, N (%) | ||||||
Bacterial infection | 1 (12.5) | 113 (36.3) | 1 (16.7) | 113 (36.1) | 7 (41.1) | 107 (35.4) |
Viral infection | 0 (0.0) | 88 (28.3) | 2 (33.3) | 86 (27.5) | 2 (11.8) | 86 (28.5) |
Fungal infection | 0 (0.0) | 2 (0.6) | 0 (0.0) | 2 (0.6) | 0 (0.0) | 2 (0.7) |
No infection | 7 (87.5) | 108 (34.7) | 3 (50.0) | 110 (35.1) | 8 (47.1) | 107 (35.4) |
Mortality, N (%) | 2 (25.0) | 26 (8.4) | 1 (16.7) | 27 (8.6) | 1 (5.9) | 27 (8.9) |
