Fig. 4: Ex vivo human prostate cancer tissue treated with boiling histotripsy. | Prostate Cancer and Prostatic Diseases

Fig. 4: Ex vivo human prostate cancer tissue treated with boiling histotripsy.

From: New kids on the block: MRI guided transrectal focused US, TULSA, focal laser ablation, histotripsy – a comprehensive review

Fig. 4

B-mode ultrasound appearance of tissue (A) pre-treatment, (B) during treatment demonstrating hyperechoic bubbles at the focus (within red oval), and (C) after treatment demonstrating a hypoechoic cavity consistent with histotripsy induced mechanical fractionation. Red arrow indicates the direction of BH sonications. Histologic appearance of H&E stained human prostate tissue from a rapid autopsy with Gleason 5 + 5 = 10 prostate cancer treated with boiling hisotripsy at low power (D), medium power (E), and high power (F). Histotripsy induced cellular fractionation is seen on lower power within the dashed boundary. At higher power sharp demarcation between treated (top half of panels E and D) and untreated tissue (bottom half of panels E and D) is seen with a boundary of ~100 μm. Untreated prostate cancer cells (black arrowhead) are present outside the treatment zone. Figure adapted from Rosnitskiy PB, et al. Ultrasonics 2023; 133: 107029 with permission.

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