Table 3 Impact of testing on patient concerns about their prostate cancer.

From: Using patient-reported outcomes from the PROCLAIM trial to assess the impact of universal germline genetic testing for prostate cancer patients

Impact of test results

No. (%) of patients

Significant differences

Significant p values

Overall [n = 485]

Positive [n = 55]

Negative [n = 215]

VUS-only [n = 215]

Reduced my concerns a lot

110 (22.7)

5 (9.1)

60 (27.9)

45 (20.9)

Neg > Pos

0.0009

Reduced my concerns somewhat

95 (19.6)

6 (10.9)

47 (21.9)

42 (19.5)

VUS > Pos

0.0423

Increased my concerns somewhat

23 (4.7)

9 (16.4)

5 (2.3)

9 (4.2)

Pos > Neg

0.0108

Increased my concerns a lot

10 (2.1)

1 (1.8)

4 (1.9)

5 (2.3)

No change

247 (50.9)

34 (61.8)

96 (44.7)

117 (54.4)

NS

NS

Impact of post-test counseling/ discussion with physician

No. (%) of patients

Significant differences

Significant p values

Overall [n = 463]

Positive [n = 53]

Negative [n = 209]

VUS-only [n = 201]

Reduced my concerns a lot

98 (21.2)

4 (7.5)

54 (25.8)

40 (19.9)

Neg > Pos

0.0009

Reduced my concerns somewhat

77 (16.6)

6 (11.3)

46 (22.0)

25 (12.4)

Increased my concerns somewhat

18 (3.9)

7 (13.2)

3 (1.4)

8 (4.0)

Pos > Neg

0.0297

Increased my concerns a lot

4 (0.9)

0 (0.0)

2 (1.0)

2 (1.0)

No change

274 (59.2)

36 (67.9)

109 (52.2)

129 (64.2)

NS

NS

  1. For analysis purposes, “a lot” and “somewhat” responses were grouped together.
  2. To account for multiple comparisons, a Bonferroni correction was applied to the p values.
  3. VUS variant of uncertain significance, NS not significant.