Fig. 1

Mutational profile of TP53 alterations. a Heatmap showing individual non-synonymous somatic mutations found in individuals administered CAR-T cell infusion (n = 60). Each row represents one type of TP53 alterations, and each column represents a patient with R/R B-NHL. The horizonal bar graph shows gene mutation frequencies. b Venn diagram demonstrates different TP53 alterations identified in 60 cases. Totally 42 (70.0%) individuals harbored TP53 mutation(s) or sole del(17p), with 27 (45.0%) and 15 (25.0%) showing TP53 mutation(s) and deletions, respectively. The remaining 18 (30.0%) cases had biallelic TP53 aberrations (TP53 mutation and del(17p) in the first and second alleles, respectively). c TP53 mutations are plotted above the protein divided into the main domains. Among the 51 mutations identified, 37 were missense mutations (yellow), 6 were splice-site mutations (blue), 4 were nonsense mutations (red), 3 were frameshift insertions or deletions (indels; purple), and 1 was a non-frameshift indel (green). Recurrent mutations were identified in 3 codons, including R273 (n = 6), R248 (n = 4) and R175 (n = 3). The x-axis indicates the amino acid position