Fig. 1
From: Pyroptosis in health and disease: mechanisms, regulation and clinical perspective
Milestones of research on the discovery and development of pyroptosis. From 1989 to 2001, pyroptosis was observed in cells, and related molecules such as IL-1β-converting enzyme (ILE) were identified. The inflammasome concept was formed and developed in the following decade. The discovery of GSDMD as an effector protein initiated the quick development of pyroptosis research with canonical, non-canonical, caspase-3/8 or granzyme-mediated pathways reported. Increasing pyroptosis studies related to specific diseases have also been performed in recent years
