Fig. 3
From: Pyroptosis in health and disease: mechanisms, regulation and clinical perspective
Regulatory mechanisms of pyroptosis in cancer. Over recent years, a series of molecules have been proven to target different sites of the pyroptosis pathway, thereby influencing the occurrence and progression of various cancers, including lung cancer, gastric cancer, breast cancer, HCC, and colorectal cancer. AZU1 Azurocidin 1, Akt protein kinase B, ASAH2 sphingolipid metabolic enzyme ceramidase, CPSF6 cleavage and polyadenylation factor 6, CHMP3 charged multivesicular body protein 3, DRD2 D2 dopamine receptor, IBSP integrin binding sialoprotein, MUC20v2 MUC20 variant 2, MMP mitochondrial membrane potential, P2X7R P2X7 receptor, PDK1 3-Âphosphoinositide-Âdependent kinase 1, Sorcin soluble resistance-related calcium-binding protein, TRAF3 tumor necrosis factor receptor-associated factor 3, TCEA3 transcription elongation factor a3, UCP uncoupling protein 1, ZNF Zinc finger protein 148. The figure was created by Figdraw
